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Kan tages med eller uden mad. Kapslerne kan åbnes. Indholdet kan opslæmmes i vand eller kommes på på blød mad, fx yoghurt eller æblemos. Nedsat nyrefunktion cobicistat will boost the level or effect of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/watch Closely. A lowered dose of tramadol may be required